深髓静脉功能障碍与大脑小血管疾病中的大脑微型出血有关
Haiyuan Lan1, Xinjun Lei1, Zhihua Xu2
1Department of Radiology, Lishui Hospital of Traditional Chinese Medicine Affiliated Zhejiang Chinese Medical University, Lishui, China.
Frontiers in human neuroscience
|September 15, 2025
概括
深髓静脉 (DMV) 功能障碍与大脑小血管疾病 (CSVD) 中的大脑微出血 (CMB) 有关. 细胞外液体积累部分调解了这种关联,这表明受损的静脉排水有助于CMB的发展.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 血管生物学 血管生物学
背景情况:
- 大脑小血管疾病 (CSVD) 是中风和认知衰退的主要原因.
- 大脑微出血 (CMB) 在CSVD中很常见,并与中风和痴呆的风险增加有关.
- 深髓静脉 (DMV) 功能障碍已与CSVD病变产生有关,但其在CMB发展中的直接作用尚不清楚.
研究的目的:
- 调查深髓静脉 (DMV) 功能障碍与CSVD患者的大脑微型血液 (CMB) 负担之间的关联.
- 确定细胞外液体积累的作用,特别是自由水 (FW) 值,以调解DMV功能障碍和CMB之间的关系.
主要方法:
- 对176名患有CSVD的患者进行了一项横截面研究.
- 深髓静脉 (DMV) 的可见性使用灵敏度加权成像 (SWI) 来评估.
- 大脑微型血流 (CMB) 被量化,并使用从扩散张力成像获得的自由水 (FW) 估计了细胞外液体体积.
主要成果:
- DMV得分与CMB负担 (r=0.460) 和FW值 (r=0.549) 有中等的正相关性.
- 患有广泛的CMB患者的DMV得分和FW值显著更高.
- 免费水 (FW) 部分调解了DMV得分和CMB负担 (β=0.088,P<0.05) 之间的关联,即使经过对共变量进行调整.
结论:
- 深髓静脉 (DMV) 功能障碍与CSVD中大脑微型血液 (CMB) 负担增加有关.
- 细胞外液体积累部分调解了这种关系,突出显示了静脉排水受损和间歇性液体保留在CMB病变发生中的潜在作用.
相关概念视频
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
294
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
294
Venous Thrombosis I: Introduction
375
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
375
Disorders of Hemostasis
2.0K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.0K
Veins of Head and Neck
5.3K
The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
5.3K
Venous Thrombosis III: Interprofessional Care
280
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
280


