饮食补充剂对绝经后女性骨循环标记物的影响:一个网络元分析
Yan Wei1,2, Congjie Lei3, Yue Zhong2
1Department of Nephropathy, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
PeerJ
|September 15, 2025
概括
维生素E,D,K,和蛋白质等食补充剂可以通过调节骨代谢和减轻骨质疏松症风险来改善绝经后妇女的骨健康. 这些补充剂影响骨循环生物标志物,为骨健康管理提供了一个有前途的策略.
科学领域:
- 内分泌学和新陈代谢学
- 营养科学 营养科学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 绝经后妇女面临骨质疏松症的风险增加,因为雌激素水平降低,影响骨矿物质密度 (BMD) 和新陈代谢.
- 食补充剂被探索为药品的替代品调节骨代谢,但证据有限.
- 一个网络元分析 (NMA) 进行了比较补充剂对绝经后妇女骨周转生物标志物的效果.
研究的目的:
- 综合比较各种食补充剂在调节骨周转生物标志物的有效性.
- 为临床医生和患者提供基于证据的指导,关于为绝经后骨健康使用补充剂.
主要方法:
- 在PubMed,Embase,Cochrane图书馆和Web of Science进行了系统的文献搜索,截至2024年11月20日.
- 包括43项随机对照试验 (RCT),涉及5184名绝经后妇女.
- 贝叶斯网络元分析 (NMA) 用于分析主要结果:CTX,P1NP,OC,BAP,ALP和NTX.
主要成果:
- 维生素E补充剂显著降低了I型原体 (CTX) 的C端端端.
- 组合维生素D和维生素K最有效地增加了I型N终端 (P1NP) 和骨质卡尔辛 (OC) 的益原蛋白.
- 维生素K,和蛋白质补充剂对骨性酸酶 (BAP),性酸酶 (ALP) 和I型原蛋白 (NTX) 的N终端端酸产生了显著的积极影响.
结论:
- 食补充剂是改善绝经后妇女骨健康的可行策略.
- 像维生素D,E,K,和蛋白质这样的特定补充剂可以促进骨的形成并抑制其再吸收.
- 这些发现表明,通过有针对性的营养干预措施,有可能减轻骨质疏松症的进展.
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