在实践正统宗教和间歇性禁食的妇女中补充维生素D3:一项具有配方特异性影响的受控研究
Spyridon N Karras1, Konstantinos Michalakis2, Maria Kypraiou3
1Laboratory of Biological Chemistry, Medical School, Aristotle University, Thessaloniki, Greece.
Metabolism open
|September 15, 2025
概括
每日补充维生素D3,以滴剂或片剂的形式,有效地改善了维生素D状态,并降低了在正教修女禁食时的甲状腺激素 (PTH) 水平. 这项研究强调了维生素D补充剂对风险人群的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 由于生活方式和禁食习惯,东正教修道院人口中常见的维生素D缺乏.
- 在这些特定群体中,对维生素D补充剂的疗效和配方效果的数据有限.
- 这项研究解决了关于恢复禁食宗教团体维生素D充足度的数据需求.
研究的目的:
- 评估每日口服维生素D3补充剂改善东正教修女维生素D状况的疗效.
- 评估维生素D3的油性滴剂和片剂配方之间的潜在疗效差异3.
- 确定补充剂对副甲状腺激素 (PTH) 水平的影响.
主要方法:
- 一项受控研究涉及41名实践间歇性禁食的东正教修女,她们每天接受2500IU维生素D3 (滴剂或片剂) 持续16周.
- 一个由40名匹配修女组成的对照组没有接受补充剂.
- 在基线和16周后测量了血清25-氧维生素D [25(OH) D]和PTH水平.
主要成果:
- 补充维生素D3的组显示平均血清25(OH) D水平显著增加 (从21.44到34.27 ng/mL) 和PTH水平显著下降 (从66.18到50.71 pg/mL).
- 对照组在25...OH) D或PTH水平上没有显著变化.
- 配方 (滴剂与片剂) 并没有显著预测维生素D度的变化,基线维生素D水平是主要预测因素.
结论:
- 每日口服维生素D3补充剂,无论配方 (滴剂或片剂),都能有效提高维生素D的状态,并降低间歇性禁食的妇女的PTH水平.
- 这些发现支持针对性维生素D补充的策略,以帮助那些处于缺乏症风险的禁食人口.
- 这项研究强调了维生素D3在改善脆弱宗教社区骨健康标志物的一般有效性.
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