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不断发展的透皮疗法:通过3D打印对自我溶解的聚合物微针进行审查
Geethu Madhusoodanan1, Amrita Arup Roy1, Tejaswini Kalkundri2
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education Manipal 576104 Karnataka India ss.mutalik@manipal.edu.
RSC advances
|September 15, 2025
概括
通过3D打印的聚合物微针 (PMN) 为通过皮肤输送药物 (TDD) 提供了一种最少的侵入性方法. 本综述探讨了它们的设计,生物相容性和成本效益高,以患者为中心的医疗保健解决方案的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 3D打印的聚合物微针 (PMN) 正在推进通过皮肤递送药物 (TDD).
- 生物相容的聚合物具有可调节的特性,但通常需要杂交以获得机械稳定性.
- 目前的局限性需要进一步的研究,以实现最佳的PMN制造和临床转化.
研究的目的:
- 审查各种微针 (MN) 设计,以提高使用3D打印PMN的TDD有效性.
- 突出物理化学性质在药物输送的增材制造中的重要性.
- 探索聚合物树脂混合物在医疗保健中的生物相容性挑战和整合潜力.
主要方法:
- 关于用于TDD的3D打印PMN技术的综合文献评论.
- 分析各种微针设计及其对药物输送效率的影响.
- 对聚合物树脂特性,生物相容性和聚合技术的评估.
主要成果:
- 3D打印的PMN为以患者为中心的药物输送提供了一个有前途的途径.
- 物理化学性质对于有效的药物输送系统的增材制造至关重要.
- 了解树脂混合的挑战是生物相容性和整合到医疗保健框架的关键.
结论:
- 3D打印的PMN具有成本高效的TDD的巨大潜力,需要进一步研究材料科学和制造工艺.
- 解决目前的研究缺口对于工业化和临床转化这项技术至关重要.
- 对PMN的战略开发可以彻底改变未来的公共医疗保健提供系统.
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