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在缺血性脑损伤中介质干细胞和外体:一篇综述

Haiyan Xu¹, Lanlan Yang², Weitie Wang³

¹Department of Rehabilitation Therapeutics, School of Nursing, Jilin University, Changchun, Jilin, China.

Frontiers in genetics

|September 15, 2025

概括

介质细胞干细胞 (MSC) 和它们的外体细胞通过帮助神经修复和减少炎症来显示中风恢复的治疗潜力. 需要进一步的研究,以克服临床应用在缺血性脑损伤方面的挑战.

科学领域:

神经科学是一个神经科学.
再生医学是一种再生医学.
生物技术是生物技术.

背景情况:

卒中是成年人死亡和残疾的主要原因,发病率不断上升.
缺血性中风后的神经修复依赖于神经血管可塑性.
介质干细胞 (MSC) 和它们的外体对治疗干预有希望.

研究的目的:

审查MSC及其外体在缺血性脑损伤中的治疗潜力.
总结MSC和外体促进神经修复的机制.
确定临床翻译的挑战和未来方向.

主要方法:

在中风中对MSC和外体细胞的临床前和临床研究的文献综述.
分析MSC和外体介导对神经血管可塑性,血管生成和神经生成的影响.
评估临床翻译当前面临的挑战.

主要成果:

MSCs和外体促进血管新生,神经新生,并减少中风后的炎症.
它们参与神经元和血管内皮细胞修复.
临床前研究表明具有显著的治疗潜力.

结论:

MSC及其外体为缺血性中风提供了一个有前途的治疗策略.
克服标准化,剂量,输送和安全方面的挑战对于临床应用至关重要.
进一步的研究对于将临床前发现转化为有效的中风疗法至关重要.

关键词:

我们的MSc是MSc.治疗方法治疗方法在外基因组中,外基因组是外基因组.它们是mRNARNA.审查审查审查审查审查审查

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相关概念视频

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...