胆管性对双胞胎出生体重异常的影响
Qiuying Li1,2,3, Hui Zhang1, Qian Chen1
1Guangzhou Key Laboratory of Neonatal Intestinal Diseases, Department of Neonatology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Translational pediatrics
|September 15, 2025
概括
与单双 (MCDA) 双胞胎相比,二双 (DCDA) 双胞胎患出生体重异常 (BWDT) 的风险较低. 这一发现对于了解双胞胎怀孕结果和新生儿健康非常重要.
科学领域:
- 产科和妇科 产科和妇科
- 新生儿健康 新生儿健康
- 生殖医学 生殖医学
背景情况:
- 先进的孕产妇年龄 (≥35岁) 正在上升,导致分娩延迟和医疗辅助生殖 (MAR) 的使用增加,这提高了双胞胎怀孕率.
- 双胞胎的出生体重异常 (BWDT),定义为体重差异>20%,与新生儿发病率的增加有关.
- 胆管性,特别是单胆管性双胞胎 (MCDA) 与二胆管性双胞胎 (DCDA),由于胎盘发育和血管连接,显著影响怀孕风险.
研究的目的:
- 调查双胞胎怀孕中胆管状况与出生体重异常 (BWDT) 的发生之间的关联.
- 为了比较二二 (DCDA) 双胞胎与单二 (MCDA) 双胞胎中BWDT的风险.
主要方法:
- 这是一项对2011年1月至2020年12月间出生的3,231对双胞胎的回顾性分析.
- 使用多变量逻辑回归来分析DCDA双胞胎和BWDT之间的关系,控制混因素.
主要成果:
- 这项研究包括498对MCDA双胞胎和2,733对DCDA双胞胎.
- 与MCDA组相比,DCDA双胞胎组表现出更高比例的晚年母亲年龄和第一次怀孕.
- 多变量逻辑回归分析显示,DCDA双胞胎与明显较低的BWDT风险有关.
结论:
- 双胞胎二二 (DCDA) 双胞胎的出生体重不一致 (BWDT) 的可能性降低.
- 胆管性是影响双胞胎怀孕BWDT风险的关键因素,DCDA双胞胎在这个方面呈现出更有利的结果.
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