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Updated: Jan 17, 2026

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Published on: February 25, 2022

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在突触和膜刺激性基因中的神秘拼接将TDP-43损失与神经元功能障碍联系起来

Caiwei Guo1, Kuchuan Chen2, Sarat C Vatsavayai3,4

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

bioRxiv : the preprint server for biology
|September 15, 2025
PubMed
概括

在像ALS和FTD这样的神经退行性疾病中,TDP-43蛋白质功能障碍会导致异常的RNA拼接,损害神经元功能. 针对这些拼接错误为这些破坏性疾病提供了潜在的治疗策略.

关键词:
在TDP-43中使用.一个神秘的拼接.膜刺激性 膜刺激性神经退行性疾病是一种神经退行性疾病.突触的功能 突触的功能

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