由波纹振荡介导的跨区域神经元共同发射支持分布式工作记忆表示
Ilya A Verzhbinsky1,2, Jonathan Daume3, Ueli Rutishauser3,4,5,6
1Neurosciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA.
bioRxiv : the preprint server for biology
|September 15, 2025
概括
高频的大脑振荡称为波,同步长距离的神经活动,增强记忆功能. 这种神经通信通过在工作记忆任务中协调大脑区域来支持认知过程.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 高频 (~90Hz) 波纹振荡与整合性大脑处理有关.
- 以前的研究将波纹的同时发生与在距离12毫米的人类皮质神经元中增强的时结合联系起来.
- 波纹合在多大程度上支持认知,并在更远的距离上运行仍然不清楚.
研究的目的:
- 调查波纹振荡的同时发生是否有助于神经元合用于认知处理.
- 要确定这种合是否发生在比先前观察到的更远的距离上.
- 检查波纹振荡在支持工作记忆中的作用.
主要方法:
- 分析从人类患者进行工作记忆任务的内记录.
- 微线电极被双边植入海马,杏仁体,腹中前额叶皮质,前带皮质和前补充运动区域.
- 在不同工作记忆阶段对波纹振荡和跨区域神经元激发模式的量化.
主要成果:
- 在编码,维护和检索期间,在所有记录的大脑区域中,波动振荡显著增加.
- 跨区域波纹的同时发生增加,伴随着跨区域共燃的~30%的增加,没有降低到220mm.
- 增加了随着记忆负载的扩展而增加的协同波动和协同发射,并在检索过程中促进了与编码相关的神经模式的恢复.
结论:
- 波动振荡编排了人类认知所必需的远程神经通信.
- 这种远程通信支持工作记忆期间的分布式神经表示.
- 波介导的同步通过在广泛的大脑网络中协调活动来促进认知功能.
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