最近的非LTR逆转移子活动预测了哺乳动物的癌症患病率
Vahid Nikoonejad Fard1, Marc Tollis1,2
1School of Informatics, Computing, and Cyber Systems, Northern Arizona University, 1295 S Knoles Dr, Bldg. 90, Flagstaff, AZ 86011, USA.
bioRxiv : the preprint server for biology
|September 15, 2025
概括
最近的逆转移素活性,特别是L1和SINE元素,与哺乳动物物种的癌症患病率相关. 这些移动元素的有限活性可以通过保持基因组稳定性来保护癌症.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 癌症研究 癌症研究
背景情况:
- 非长端重复逆转移体 (nLTRs),包括L1和SINEs,是哺乳动物基因组中丰富的移动元素.
- 这些元素在瘤发生过程中在突变发生和基因调节中发挥作用.
- 最近的nLTR活动与人类以外的特定物种癌症风险之间的关系在很大程度上是未知的.
研究的目的:
- 调查最近的nLTR活动是否预测不同哺乳动物物种的癌症患病率.
- 分析不同nLTR活动指标与癌症风险之间的关联.
- 探索NLTRs在癌症发展中的作用和潜在的保护机制.
主要方法:
- 对55种哺乳动物的 de novo重复注释进行了比较基因组分析.
- 对nLTR活动的量化:活性元素的数量,与基因的接近,以及基因插入.
- 从动物园病理记录中获得的nLTR活动指标和癌症患病率数据之间的相关性分析.
主要成果:
- 与L1和联合L1-SINE活动相关的新生病患病率.
- 与L1-SINE活性相关的恶性病变,表明其作用正在升级.
- 更高的癌症基因正基因 (CGO) 计数与瘤患病率相关.
- 融合癌基因数量与活性L1元素有很强的相关性.
- 癌症发病率较低的物种显示至少一个nLTR超级家族的活性受到限制.
结论:
- 最近的nLTR活动,特别是L1和SINEs,是哺乳动物癌症患病率和恶性瘤的重要预测因素.
- L1元素可能会启动瘤发生,而SINEs会放大效应,导致恶性瘤.
- 通过限制逆转换来维持基因组稳定性,似乎可以保护癌症.
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