肺中的形态发生的生物物理机制
Kaleb Hill1, Aaron H Griffing1,2,3, Michael A Palmer1,4
1Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544.
bioRxiv : the preprint server for biology
|September 15, 2025
概括
状爬行动物的肺部发育有所不同; 虽然有些人使用应力球形态发生,但其他人使用上皮质折叠或尖端收缩. 这些独特的机制创造了多样化的肺结构,影响了适应.
科学领域:
- 比较的发育生物学.
- 进化形态学的进化形态学
- 脊椎动物的胚胎学
背景情况:
- 状爬行动物肺部 (和蛇) 的结构呈现出显著的多样性,从简单的囊袋到复杂的带有分泌体的腔体器官.
- 骨中的胚胎肺部发育涉及应力球形态发生,其中光液压力通过光滑肌肉网驱动上皮质突起.
研究的目的:
- 为了研究在不同状动物物种的胚胎肺部发育中压力球形态发生的保护.
- 阐明在状肺中形成过渡腔和分流器的物理机制.
主要方法:
- 对棕色,子和蒙面黑猩猩的胚胎肺部发育进行比较分析.
- 实验操纵和计算建模以了解形态遗传过程.
- 在胚胎发育过程中对肺组织进行组织学检查.
主要成果:
- 通过肺平滑肌肉网的上皮质突起在研究的状动物物种中保持着.
- 亮度膨胀并非普遍保存;甲和蒙面黑猩猩利用表皮的折叠和增殖.
- 蒙面黑猩猩的过渡腔和分歧细胞通过顶尖收缩发展,这种机制也在鸟类肺部呼吸道分支中见到.
结论:
- 独特的形态遗传机制有助于在状动物肺部观察到的多样化的上皮结构.
- 这些多样化的发育途径可能在和蛇的特定物种生理和生态适应中发挥作用.
相关概念视频
Gross Anatomy of the Lungs
4.3K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
4.3K
Mechanism of Breathing I: Inspiration
3.1K
Introduction to Inspiration: The Respiratory System in Action
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
3.1K
Anatomy of Respiratory System II: Lower Respiratory Tract
3.3K
The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
3.3K
Breathing
64.2K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
64.2K
Gastrulation
66.5K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
66.5K
Mechanism of Breathing III: The Accessory Muscles
4.2K
The Role of Accessory Muscles in the Respiratory System
The respiratory system is a complex network that relies on primary respiratory muscles like the diaphragm, but also involves accessory muscles to enhance lung expansion and airflow during both inhalation and exhalation.
Enhancing Inhalation with Accessory Muscles:
Accessory muscles such as the sternocleidomastoid, scalene, intercostal, and abdominal muscles are crucial when additional respiratory effort is required, such as during deep...
The respiratory system is a complex network that relies on primary respiratory muscles like the diaphragm, but also involves accessory muscles to enhance lung expansion and airflow during both inhalation and exhalation.
Enhancing Inhalation with Accessory Muscles:
Accessory muscles such as the sternocleidomastoid, scalene, intercostal, and abdominal muscles are crucial when additional respiratory effort is required, such as during deep...
4.2K


