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Updated: Jan 17, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

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PRDM1通过在光暗区过渡期间关闭染色质可访问性来塑造生殖中心B细胞的克隆多样性

Godhev Kumar Manakkat Vijay, Bala Ramaswami, Steven Gierlack

    bioRxiv : the preprint server for biology
    |September 15, 2025
    PubMed
    概括

    蛋白质PRDM1 (BLIMP1) 意外地抑制了生殖中心B细胞的反应. 失去PRDM1会导致B细胞反应过度,并增加克隆主导,影响免疫多样性.

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    Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation11:06

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    相关概念视频

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    In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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