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Updated: Jan 17, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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Published on: December 16, 2021

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表观遗传调节的p53活性维持肠调节T细胞的身份,以防止炎症

Stephanie Silveria, Janneke Gc Peeters, Jenna Vickery

    bioRxiv : the preprint server for biology
    |September 15, 2025
    PubMed
    概括

    瘤抑制剂p53通过防止对免疫平衡至关重要的Foxp3的损失来稳定调节性T细胞 (Tregs). 这一发现为炎症性肠病 (IBD) 提供了潜在的治疗点.

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