糖尿病病中内皮细胞功能障碍和细胞损伤之间的相互作用:对当前证据的全面审查
Shuai Guo1, Hong-Min Luo1, Ling-Ling Wang1
1Hebei Medical University Third Hospital Shijiazhuang 050051, Hebei, China.
American journal of translational research
|September 15, 2025
概括
糖尿病病症涉及脏内皮细胞和细胞之间的交叉声,驱动疾病. 针对这种相互作用的疗法为保持功能提供了希望.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 糖尿病学 糖尿病学
- 细胞生物学 细胞生物学
背景情况:
- 糖尿病病是末期病的主要原因.
- 淋巴体内皮细胞 (GEC) 功能障碍和足细胞损伤是糖尿病病进展的关键驱动因素.
- GECs和podocytes之间的相互作用对于保持质透屏障 (GFB) 完整性至关重要.
研究的目的:
- 审查在糖尿病病中GECs和podocytes之间的交叉声的基础上的分子机制.
- 探索与这种内皮细胞-细胞轴干扰相关的临床相关性和生物标志物.
- 要总结针对这种相互作用的新兴治疗策略,以潜在治疗糖尿病病.
主要方法:
- 文献综述综合了有关糖尿病病原病的当前研究.
- 对分子机制的分析,包括氧化应激,血管生成和细胞外囊泡 (EV) 介导的信号传递.
- 整合多主题数据,提出一种统一的疾病和精准医学模型.
主要成果:
- 高血糖引起的氧化应激,血管生成失调和异常的EV信号制造出球损伤的循环.
- 反映内皮细胞 - 足细胞轴干扰的生物标志物预测疾病进展和治疗反应.
- 像SGLT2抑制剂和MSC衍生的EVs这样的新疗法在恢复GFB完整性方面显示出希望.
结论:
- GECs和podocytes之间的双向交叉声是糖尿病病的核心.
- 针对这一轴为新型治疗干预提供了一个有希望的途径.
- 精准医学方法整合多omics见解可以个性化治疗糖尿病病.
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