相关实验视频

Updated: Jan 17, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

血清生物标志物用于诊断和评估膝关节骨关节炎的严重程度

Fang Li¹, Jia-Yi Yao², Jing-Jing Cao¹

¹Department of Preventive Medicine, Hebei General Hospital Shijiazhuang 050051, Hebei, China.

American journal of translational research

|September 15, 2025

概括

信号传感器和转录3激活剂 (STAT3),血管内皮生长因子 (VEGF),以及IL-2和IL-4的血清水平升高与膝关节关节炎 (KOA) 的严重程度有关. 这些生物标志物显示出KOA诊断和评估的潜力.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
整形外科整形外科整形外科

背景情况:

膝关节骨关节炎 (KOA) 是一种具有复杂病理生理学的退行性关节疾病.
诊断KOA和评估其严重程度的生物标志物对于有效管理至关重要.

研究的目的:

在KOA患者中调查STAT3,VEGF,IL-2和IL-4的血清水平.
评估这些生物标志物对KOA和疾病严重性的诊断价值.

主要方法:

分析了来自115名KOA患者和50名健康对照者的血清样本.
使用免疫检测技术量化了STAT3,VEGF,IL-2和IL-4的水平.
通过ROC曲线分析评估了与KOA严重程度和诊断准确度的相关性.

主要成果:

与对照组相比,KOA患者的STAT3,VEGF,IL-2和IL-4血清水平显著更高 (P <0.05).
这些生物标志物的度在治疗后下降,表明与治疗疗效的相关性.
生物标志物对KOA (AUC从0.704到0.797) 和严重性评估 (AUC从0.723到0.769) 显示出良好的诊断准确性.

结论:

血清STAT3,VEGF,IL-2和IL-4的升高与KOA的严重程度和治疗反应有关.
这些生物标志物有可能作为KOA及其严重程度评估的辅助诊断指标.

关键词:

膝关节骨关节炎是一种关节炎.介质蛋白-2 介质蛋白-2 介质蛋白-2 介质蛋白-4 介质蛋白-4 信号传感器和转录的激活器 3 3 血管内皮生长因子血管内皮生长因子

更多相关视频

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...

Serum Studies: Renal Function Tests

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.