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随着局部晚期食道状细胞癌的同时化疗和放射治疗后的肉类症
Thiranai Vongcharoenpol1, Wongsakorn Chaochankit1, Sakchai Ruangsin1
1Department of Surgery, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Journal of gastrointestinal oncology
|September 15, 2025
概括
同时化学放射治疗 (CCRT) 在患有局部晚期食道状细胞癌 (ESCC) 的患者中恶化了肉症. 大多数患者在治疗前患有肉类,CCRT导致骨肌指数 (SMI) 降低.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 胃肠病学 胃肠病学
背景情况:
- 局部发达的食道状细胞癌 (ESCC) 通常用化疗,放射治疗和手术治疗.
- 肉症是食道癌患者常见的疾病,可能会受到同时化学放射治疗 (CCRT) 的影响.
- 在局部发达的ESCC中,CCRT对肉类的影响尚不清楚.
研究的目的:
- 评估CCRT对局部发达ESCC患者的肉症的影响.
- 在CCRT前后评估骨肌肉指数 (SMI) 的变化.
- 探索萨科佩尼亚,存活率和治疗毒性之间的关联.
主要方法:
- 在2011年至2020年期间,对213名局部发达ESCC患者进行了回顾性分析,这些患者接受了CCRT治疗.
- 通过CT扫描在L3脊椎使用骨肌肉指数 (SMI) 评估萨尔科佩尼亚.
- 使用CCRT前后的CT扫描来测量SMI,包括psoas,副脊柱和腹壁肌肉.
主要成果:
- 在CCRT之前,83.6%的患者患有肉;在非肉患者中,CCRT后48.6%的患者患有肉.
- 在sarcopenic和非sarcopenic组中,CCRT显著降低了SMI.
- 起始时的肉类与生存或CCRT毒性没有显著的相关性;男性,高N阶段和下降的BMI后CCRT与较差的生存有关.
结论:
- 大多数局部发达的ESCC患者表现出肉症,CCRT加剧了这种情况.
- 建议在治疗前对萨尔科佩尼亚进行评估和早期干预策略,以管理萨尔科佩尼亚状态.
- 对萨尔科佩尼亚管理的进一步研究可能会改善ESCC患者的治疗结果.
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