相关实验视频

Updated: Jan 17, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

Published on: February 25, 2016

氧化抵抗与胰岛素耐药肥胖儿童的血管和心肌功能障碍有关:一项新型大动脉应变研究

Antoine Fakhry AbdelMassih^1,2, Fatma Alzahraa Mostafa¹, Marianne Edward Yassa³

¹Department of Pediatrics, Pediatric Cardiology Unit, Cairo University Children Hospital, Cairo University, Cairo, Egypt.

Journal of cardiovascular echography

|September 15, 2025

概括

肥胖导致较高的氧化 (NOx) 水平,这表明胰岛素抵抗会影响NO的生物可用性. 这种与大动脉应变率相关的血管功能障碍会影响心肌功能,特别是在心下内脏.

科学领域:

心血管生理学心血管生理学
代谢障碍代谢障碍代谢障碍
生物化学生物化学

背景情况:

已知肥胖会损害血管顺应性和心肌功能.
肥胖引起的心血管功能障碍背后的确切机制尚不清楚.
关于肥胖中氧化 (NOx) 调节的证据存在矛盾.

研究的目的:

为了研究肥胖个体的NOx状态.
为了将NOx水平与血管功能参数相关联.
确定在肥胖中血管功能障碍和心肌功能之间的关系.

主要方法:

招募了20名肥胖患者和16名健康对照.
测量了血清NOx水平和食后C-与葡萄糖比率 (PCPRI).
使用流媒扩张 (FMD) 和大动脉应变率 (ASR) 评估了血管功能.
用斑点跟踪回声心脏成像来评估心肌功能.

主要成果:

肥胖患者的血清NOx明显高 (106 ± 14) 与对照组 (62 ± 9) 相比.
增加的PCPRI (表明胰岛素耐药性) 与更高的NOx水平相关,这表明胰岛素诱导的NOx耐药性.
ASR与血清NOx (r=0.86) 呈现出强烈的相关性,比口疫 (r=0.66) 更强烈.
降低ASR与心肌功能受损有关,特别是心下内脏的全球纵向应变 (r=0.77).

结论:

肥胖相关的血管功能障碍可能源于高胰岛素血症诱导的氧化耐药性.
这种血管功能障碍似乎显著降低了心肌功能,特别是由于血液供应受损害,影响心下内脏区域.

关键词:

大动脉应变率的速度.氧化耐受性的耐氧化.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖

更多相关视频

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

相关概念视频

Nitric Oxide Signaling Pathway

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...