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探索辅酶Q10对女性生育能力的保护作用

Yu Jiang^1,2, Yao Han^1,2, Pengyun Qiao^1,2

¹Department of Reproductive Medicine, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, China.

Frontiers in cell and developmental biology

|September 15, 2025

概括

辅酶Q10 (CoQ10) 补充剂通过提高卵细胞质量和卵巢功能来改善女性生育能力和辅助生殖技术 (ART) 的成功. 它为不孕症提供了一个有前途的治疗策略,特别是在老年妇女或卵巢储量减少的妇女中.

科学领域:

生殖医学生殖医学
生物化学生物化学
细胞生物学细胞生物学

背景情况:

全球生育率正在下降,人们越来越依赖辅助生殖技术 (ART).
抗氧化剂补充剂,特别是辅酶Q10 (CoQ10),正在探索改善生育能力和ART结果.
辅酶Q10是一种重要的脂溶性诺基,参与线粒体能量代谢和抗氧化剂防御.

研究的目的:

审查辅酶Q10保护女性生育能力的机制.
综合有关CoQ10对卵细胞质量,卵巢功能和ART成功的影响的证据.
探索CoQ10在管理诸如早产卵巢衰竭和多囊性卵巢综合征等疾病方面的潜力.

主要方法:

文献综述综合了关于辅酶Q10和女性生育能力的当前证据.
对CoQ10在线粒体功能和氧化应激调节中的生化作用的分析.
对辅酶Q10补充和ART结果的临床研究数据的检查.

主要成果:

辅酶Q10调节氧化应激,减少活性氧物种 (ROS),提高卵细胞质量和线粒体效率.
临床研究表明,辅酶Q10补充可以改善卵巢功能,卵子产量和胚胎质量,特别是在老年妇女或卵巢储备减少的妇女身上.
辅酶Q10对卵细胞成熟,胚胎发育和卵巢衰老具有保护作用.

结论:

辅酶Q10是增强女性生育能力和ART成功的有前途的治疗剂.
它的抗氧化和增强线粒体的特性为生殖健康提供了显著的好处.
对于 CoQ10 在生殖医学中的进一步临床应用指南是有必要的.

关键词:

艺术艺术艺术艺术在 CoQ10 中,这就是ROSOS ROS.女性不孕症女性不孕症氧化应激是一种氧化应激.

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