怀孕不良结果的女性心血管疾病的差异

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Updated: Jan 17, 2026

06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

14.1K

Maria Natalia Chaves Rivera¹, Santiago Clocchiatti-Tuozzo^2,3, Daniela Renedo⁴

¹Department of Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, New Haven, CT.

medRxiv : the preprint server for health sciences

|September 15, 2025

概括

负面的妊娠结果 (APOs) 增加了心血管疾病 (CVD) 的风险,特别是在黑人妇女中. 将生殖史与社会决定因素相结合,可以改善心血管疾病预防和健康公平.

科学领域:

生殖健康生殖健康
心血管疾病流行病学
健康差异在健康上的差异

背景情况:

不良妊娠结果 (APOs) 与心血管疾病 (CVD) 风险有关.
之前的研究往往忽视了多样化的人口.
这项研究研究了APOs,种族和种族对心血管疾病风险的协同作用.

研究的目的:

测试APO和种族/种族协同增加心血管疾病风险的假设.
分析与妊娠并发症和人口因素相关的心血管疾病风险.
为个性化心血管疾病预防策略提供信息.

主要方法:

对多样化的"我们所有人"研究队列的回顾性分析.
纳入标准:一生只分娩过一次,没有先前心血管疾病的妇女.
暴露:APO (孕前,妊娠期糖尿病等) 的情况. 和自我报告的种族/种族.
结果:发生心血管疾病 (中风,心肌梗塞,心力衰竭) ≥1年产后.
统计分析:多变量考克斯比例危险模型与相互作用条件.

主要成果:

分析了10,760名女性;39%的女性至少经历过一次APO.
APO与显著增加心血管疾病风险相关 (HR:1.45).
APO与种族/种族之间的显著相互作用 (p=0.003).
与没有APO的白人女性相比,拥有APO的黑人女性心血管疾病风险高出四倍 (HR:4.04).
患有APO的白人女性心血管疾病风险增加了两倍 (HR: 2.01).

结论:

在多元化的美国女性中,APO增加了心血管疾病风险.
这种风险在黑人女性中大大增加.
整合生殖健康史和社会决定因素对于预防心血管疾病和健康公平至关重要.
需要进一步的研究来阐明这些协同效应背后的机制.

关键词:

负面的怀孕结果.在健康方面存在差异.心脏病心脏病心脏病一次性中风,中风.心血管疾病心血管疾病健康的非医学决定因素

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