在手术中,电刺激可以替代自发发作吗?
William K S Ojemann1,2, Caren Armstrong3,4, Akash Pattnaik1,2
1Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
medRxiv : the preprint server for health sciences
|September 15, 2025
概括
在内EEG (iEEG) 评估期间的电刺激 (stim) 发作有助于确定产生的组织. 刺激性发作招募较小的网络,它们的发作区域与自发性发作重叠,这表明它们识别了性发作组织.
科学领域:
- 神经科学是一个神经科学.
- 发病学 (Epileptology) 是一个专业的学科.
- 医疗器械技术 医疗器械技术
背景情况:
- 内EEG (iEEG) 对于手术的评估至关重要.
- 电刺激 (刺激) 发作用于定位发作发作区域.
- 与自发性相比,刺激性的诊断价值尚未完全理解.
研究的目的:
- 为了比较刺激性和自发性的网络招募模式.
- 评估刺激发作在识别发性组织方面的有用性.
- 评估刺激映射的潜力,作为记录自发发作的替代方案.
主要方法:
- 分析了105名患者的多中心队列.
- 441次低频 (1 Hz) 刺激发作和自发发作进行了比较.
- 使用了一种经过验证的自动发作映射算法.
主要成果:
- 刺激性发作比自发性发作招募了更小,更受限制的网络.
- 刺激性发作发作区域与自发性发作发作和传播重叠.
- 刺激性发作首选来源于 mesial 时结构,特别是在成人发作的中.
结论:
- 刺激性发作提供了对网络的空间限制视图.
- 刺激发作发作区域反映了底层的发性组织.
- 刺激映射可能是一个有价值的工具,用于识别手术的目标和预测发作复发.
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