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Updated: Jan 17, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
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化学修饰对血红蛋白对人类心脏肌细胞的毒性的影响

Sirsendu Jana1, Haley Garbus-Grant1, Tigist Kassa1

  • 1Laboratory of Biochemistry and Vascular Biology, Center for Biologic Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

Frontiers in molecular biosciences
|September 15, 2025
PubMed
概括

基于血红蛋白的氧载体 (HBOC) 的较高氧化状态会导致显著的心脏细胞损伤和线粒体功能障碍. 了解这些氧化还原状态对于开发更安全的血液替代品至关重要.

关键词:
心脏 AC1616 的心脏细胞毒性 细胞毒性基于血红蛋白的氧气载体 (HBOCs)线粒体的分数线粒体的分数氧化还原反应 氧化还原反应

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