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乳腺癌和正常邻近组织中的微生物群体概况:与临床病理学特征的关联

Dengfeng Xue¹, Chunhui Wu¹, Ruihong Hou²

¹Department of Breast Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.

Translational cancer research

|September 15, 2025

概括

乳腺癌 (BC) 微生物群在瘤和正常组织之间存在差异,像Brevundimonas这样的特定细菌与高增殖有关. 这些发现为基于微生物群的BC疗法提供了潜在的目标.

科学领域:

微生物学微生物学
在瘤学瘤学.
基因组学就是基因组学.

背景情况:

乳腺组织中的微生物影响乳腺癌 (BC) 的发展和进展.
了解BC相关的微生物群对于识别致病机制和改进诊断和治疗至关重要.

研究的目的:

使用16S核糖体RNA (rRNA) 测序来描述与乳腺癌相关的微生物群.
探索潜在的致病机制,并确定早期诊断和个性化治疗BC的目标.

主要方法:

从31个BC患者的瘤和正常邻近组织 (NAT) 的16SrRNA测序.
分析使用简短的多个地区框架 (SMURF) 管道.
多样性分析和差异性分类体鉴定 (威尔科克森标记级别测试,LEfSe),具有功能途径预测 (KEGG).

主要成果:

在BC和NAT组之间,α或β多样性没有显著差异.
在BC组织中丰富Flavobacteriales,Comamonas和Delftia.
在BC中受调节的途径包括酸/阿尔达酸代谢和甘氨酸降解.
在高Ki-67 (H-Ki-67) 样本中,Brevundimonas占主导地位,其糖解和细菌毒素通路的高调节.

结论:

在BC组织和临床病理学亚组中存在不同的微生物特征,尽管整体多样性相似.
布鲁文迪莫纳斯 (Brevundimonas) 是H-Ki-67群中的一个占主导地位的属.
这项研究提供了有关BC的微生物机制和潜在的基于微生物群的治疗点的见解.

关键词:

乳腺癌 (BC) 是一种癌症.生物标志物生物标志物功能预测的功能预测.微生物社区的微生物社区.正常的邻近组织 (NAT)

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