SHOX-2甲基化的诊断准确性对于恶性多流液:一个系统的审查和元分析
Hao-Jie Wang1,2, Jian-Ying Cui1,2, Wen-Jie Hou2,3
1Department of Respiratory and Critical Care Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Translational cancer research
|September 15, 2025
概括
SHOX-2甲基化显示了恶性多叶流血 (MPE) 的中度诊断准确性. 这项对六项研究的元分析发现MPE诊断的综合灵敏度为0.64和特异性为0.96.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 恶性多叶流血 (MPE) 诊断可能具有挑战性.
- 之前对SHOX-2甲基化用于MPE诊断的研究产生了不一致的结果.
研究的目的:
- 系统地审查和元分析SHOX-2甲基化对MPE的诊断准确性.
主要方法:
- 在PubMed和Web of Science数据库中搜索到2024年12月.
- 包括六项研究,包括613名MPE和723名良性流 (BPE) 患者.
- 使用双变量模型进行元分析和sROC曲线进行整体准确性评估.
主要成果:
- 对于SHOX-2甲基化的聚合灵敏度为0.64 (95% CI:0.36-0.85).
- 聚合的特异性为0.96 (95% CI:0.92-0.98).
- 在sROC曲线下的面积为0.96 (95%CI:0.94-0.97),没有出版偏差.
结论:
- SHOX-2甲基化显示出适度的诊断价值,用于识别MPE.
- 这些发现支持SHOX-2甲基化作为MPE诊断中的潜在生物标志物.
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