在患有焦虑障碍的儿童中,氧化应激和硫化血静
Armagan Aral1, Bahattin Avcı2, Neriman Kesim3
1Child and Adolescent Mental Health and Diseases, Izmir City Hospital, İzmir, Türkiye.
Noro psikiyatri arsivi
|September 15, 2025
概括
像总氧化剂状态 (TOS) 这样的氧化应激标志物在患有焦虑障碍 (AD) 的儿童中升高,这表明潜在的氧化功能障碍. TOS可以作为儿科阿尔茨海默病的生物标志物,尽管硫化/硫化平衡保持不变.
科学领域:
- 儿科医学 儿科医学
- 生物化学 生物化学
- 心理健康研究 心理健康研究
背景情况:
- 焦虑障碍 (AD) 是普遍存在的精神健康问题,其病因不明.
- 氧化应激,指的是被破坏的氧化剂/抗氧化剂平衡,涉及到AD.
- 在儿科阿尔茨海默病中氧化应激的研究是有限的,需要进一步的研究.
研究的目的:
- 在患有阿尔茨海默氏症的儿童中调查总氧化剂/抗氧化剂状态 (TOS/TAS) 和醇/二硫化物平衡 (TDH).
- 为了确定小儿AD的潜在氧化应激生物标志物.
- 探索氧化应激在儿科阿尔茨海默病的发病过程中的作用.
主要方法:
- 一项病例控制研究,涉及40名患有AD的儿童和40名健康对照.
- 评估社会人口统计数据和焦虑症状使用儿童焦虑相关情绪障碍屏幕 (SCARED).
- 对TOS,TAS和TDH的生物化学分析.
主要成果:
- 与对照组相比,患有AD的儿童表现出高TOS和氧化应激指数 (OSI),TAS降低.
- 在AD和对照儿童之间没有观察到TDH的显著差异.
- 后勤回归将TOS确定为儿科AD的显著预测因素 (p=0.027).
结论:
- 氧化功能障碍可能在儿科阿尔茨海默病中起作用.
- TOS显示了作为区分儿科AD的生物标志物的潜力.
- 缺少TDH变化表明,在儿科阿尔茨海默病中存在其他氧化应激途径,这需要进一步的研究和临床试验.
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