在新辅助疗法期间营养支持对食道癌术后结果的影响:现实世界队列研究
Yongbo Yang1, Yan He1, Wan Wei1
1First Department of Thoracic Surgery, Peking University Cancer Hospital & Institute, Beijing, China.
Journal of thoracic disease
|September 15, 2025
概括
在食道癌的新辅助治疗期间有效的营养支持可以改善患者的治疗结果. 保持或增加体重可以提高治疗完成率,减少不良事件,并降低静脉漏风险.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 营养科学 营养科学
背景情况:
- 为食道癌建立了术后营养支持.
- 在食道癌的新辅助疗法期间的营养干预尚未得到研究.
- 这项研究侧重于新辅助疗法期间营养支持对术后结果的影响.
研究的目的:
- 调查新辅助疗法期间营养支持的作用.
- 为了评估其对食道癌症患者术后结果的影响.
主要方法:
- 对454名食道切除术患者的回顾性分析.
- 患者分为营养有效 (体重增加/维持) 和控制 (体重减轻) 组.
- 术前营养状况,治疗完成,不良反应和术后结果的比较.
主要成果:
- 营养有效组显示营养状况改善 (更高的BMI变化,较低的NRS得分).
- 观察到更高的新辅助疗法完成率 (82.9%与74.7%) 和更少的等级≥3不良反应 (13.8%与21.3%).
- 在营养有效组中,手术后解剖漏率降低 (10.2%与17.3%相比).
结论:
- 鼻胃管食对于有效的新辅助营养支持至关重要.
- 营养干预改善了手术前状态,治疗完成,并减少了不良事件和静脉漏.
- 对改善术后病理缓解的潜在贡献.
相关概念视频
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
853
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
853
Enteral Nutrition I: Orogastric and Nasogastric Feeding
1.3K
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
1.3K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
644
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
644
Barrett Esophagus-II: Clinical Manifestations and Management
802
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
802
Esophageal Strictures-II: Clinical Features and Management
439
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
439
Esophageal Varices-II: Clinical Features and Management
376
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
376


