遗传风险因素调节了身体活动与结直肠癌之间的关联
Anita R Peoples1, Mireia Obón-Santacana2, Andre E Kim3
1American Cancer Society.
Research square
|September 15, 2025
概括
身体活动可以防止结肠直肠癌 (CRC),这项研究发现了两种修改这种保护作用的基因变异. 这些发现表明,在CRC预防中,身体活动影响的特定途径.
科学领域:
- 遗传学 是一个遗传学.
- 癌症研究 癌症研究
- 流行病学 流行病学
背景情况:
- 身体活动 (PA) 是已知的对结直肠癌 (CRC) 的保护因素.
- 遗传变异对PA和CRC风险之间的关系的影响在很大程度上仍未被探索.
- 研究基因环境相互作用对于理解CRC病因学至关重要.
研究的目的:
- 进行全基因组基因-PA相互作用分析,以确定修改PA对CRC风险的保护作用的遗传变异.
- 探索涉及PA-CRC关联的潜在生物途径.
主要方法:
- 进行了全基因基因-PA相互作用分析,使用后勤回归和两步/联合测试.
- 身体活动水平被分类为活跃与不活跃以及研究和性别特定的四分位数.
- 在CRC风险方面,评估了常见遗传变异和PA之间的相互作用.
主要成果:
- 身体活动显示出对CRC的整体保护作用 (OR=0.85).
- 发现了跨基因变异rs4779584 (接近GREM1/SCG5) 和PA之间的相互作用 (p=2.6×10−8). 只有在具有CC基因型的个体中,PA的保护作用是显著的.
- 发现了与基因间变异rs56906466 (接近KCNG1) (p=3.5×10−8) 的另一种相互作用. 增加的PA与较低的CRC风险仅在TT运营商中相关.
结论:
- 两种基因变异rs4779584和rs56906466被确定为显著改变PA和CRC风险之间的关联.
- 接近GREM1/SCG5的变体表明,BMP相关的,炎症性或胰岛素信号通路可能参与PA对结直肠癌的保护作用.
- 这些发现强调了在CRC预防策略中考虑基因-PA相互作用的重要性.
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