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Updated: Jan 17, 2026

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对各种恶性瘤中PET/CT图像重建的Ordered Subset Expectation Maximization和贝叶斯惩罚性概率算法的比较评估,使用F-FDG和68Ga-PSMA-11追踪器

Arvin Naeimi^1,2, Sara Harsini³, Ramin Akbarian Aghdam⁴

¹Department of Radiology, McGill University Health Center, McGill University, Montreal, QC, Canada.

Frontiers in oncology

|September 15, 2025

概括

贝叶斯惩罚概率 (BPL) 和有序子集预期最大化 (OSEM) PET/CT重建算法显示出临床效用. 虽然BPL产生了更高的定量指标,但存在显著的变化,这表明在没有协调的情况下谨慎进行纵向研究.

科学领域:

核医学是一种核医学.
医学成像医学成像
放射化学放射化学是指辐射化学.

背景情况:

阳离子辐射断层扫描/计算机断层扫描 (PET/CT) 对于癌症诊断和监测至关重要.
像OSEM和BPL (Q.Clear) 这样的图像重建算法会影响定量准确性.
标准化摄入值 (SUV) 和瘤与背景比率 (TBR) 是关键指标.

研究的目的:

为了比较OSEM和BPL算法的性能,用于PET/CT图像重建.
评估这些算法对使用18F-FDG和68Ga-PSMA-11追踪器的定量指标的影响.

主要方法:

对33名患者 (25名FDG,8名PSMA) 的回顾性分析.
使用OSEM和BPL算法重建的PET/CT扫描.
评估包括SUVmax,SUVpeak,背景SUV和TBR在内的定量指标.

主要成果:

在FDG和PSMA组中,与OSEM相比,BPL通常产生更高的定量值 (SUVpeak,TBR).
在BPL和OSEM指标之间观察到强烈的线性相关性 (r>0.85).
布兰德-阿尔特曼分析揭示了广泛的共识范围,特别是PSMA成像中的TBR,这表明存在相当大的变化.

结论:

OSEM和BPL算法都在临床上有用,BPL增强了一些定量指标,但没有显著改善病变检测.
由于观察到的可变性,BPL和OSEM的直接可互换性是有限的,特别是在纵向研究中.
建议采用协调策略和一致使用重建方法,以便在多中心或纵向环境中可靠量化.

关键词:

BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL BPL 贝叶斯主义者惩罚了概率.这就是OSEMEM OSEM.订制子集预期最大化最大化聚乙烯/聚乙烯/聚乙烯 positron发射断层扫描-计算机断层扫描图像重建图像重建标准化吸收值是标准化的吸收值.

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