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孕期糖尿病:导致长期甲状腺功能障碍和疾病的原因之一.
Yu-Hsiang Shih1,2, Chia-Jung Hsieh1, Shao-Jing Wang1
1Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan.
孕期糖尿病 (GDM) 增加了甲状腺疾病的长期风险,如甲状腺功能过高和甲状腺功能低下. 以前患有GDM的女性应接受延长的甲状腺监测,特别是如果老年或超重.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 孕期糖尿病 (GDM) 越来越多地与甲状腺功能障碍有关.
- 在GDM后临床诊断的甲状腺疾病的长期风险需要进一步调查.
研究的目的:
- 为了评估长期发生的特定的甲状腺疾病在女性有史以来GDM相比没有.
- 为了确定与以前的GDM相关的特定甲状腺疾病.
主要方法:
- 使用美国TrinetX网络 (>80个医疗保健机构) 的回顾性队列研究.
- 包括在2001-2015年间怀孕的16-45岁妇女,不包括那些有先前存在的疾病的妇女.
- 倾向性得分匹配 (1:1) 和考克斯模型被用来分析20年后的结果.
主要成果:
- GDM与甲状腺功能过高 (HR1.60),甲状腺功能下降 (HR1.33),甲状腺炎 (HR1.55),哈希莫托甲状腺炎 (HR1.37),有毒胆囊 (HR1.70) 和非有毒胆囊 (HR1.26) 的风险显著增加.
- 没有观察到良性甲状腺瘤或甲状腺癌的风险增加.
- 高风险在35-45岁的女性和BMI>25.5的女性中更为明显.
结论:
- 孕期糖尿病与各种甲状腺疾病的长期风险增加有关.
- 推扩展甲状腺监测对于有GDM病史的女性,特别是那些年长或超重/肥胖的女性.
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