实验室衍生的炎症比率作为早期冠状动脉疾病的新型诊断模型
Fujia Guo1, Min Xu1, Qingxian Tu1
1Cardiovascular Medicine, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi Medical University, Zunyi, China.
Frontiers in endocrinology
|September 15, 2025
概括
新的炎症生物标志物,特别是阿波利波蛋白B与阿波利波蛋白A-1的比率 (apoB/apoA-1),显示出确定早发性冠状动脉疾病 (PCAD) 的希望. 包括apoB/apoA-1在内的组合模型显著提高了PCAD的诊断准确性.
科学领域:
- 心脏病学 心脏病学
- 生物标志物发现发现
- 预防医学 预防医学
背景情况:
- 早发性冠状动脉疾病 (PCAD) 影响年轻人,并且经常被当前的风险工具无法检测到.
- 患有PCAD的年轻患者经常进行正常的体检,但后来经历了急性心血管事件.
研究的目的:
- 评估新型炎症生物标志物的诊断性能,以识别早发性冠状动脉疾病 (PCAD).
- 在PCAD查中评估MHR,PLR,NLR,LMR,apoB/apoA-1和LDL-c/HDL-c等生物标志物的有用性.
主要方法:
- 对1012名接受冠状动脉血管造影的年轻人进行了回顾性分析.
- 分为PCAD病例 (n=521) 和对照组 (n=491) 的分层.
- 统计分析包括曼·惠特尼U测试,逻辑回归和ROC曲线分析,以评估生物标志物的性能.
主要成果:
- 阿波利波蛋白B与阿波利波蛋白A-1的比率 (apoB/apoA-1) 显示出与PCAD的最强相关性 (OR=6.268).
- 在单个生物标志物中,apoB/apoA-1比率显示了最高的诊断准确性 (AUC=0.771).
- 一个综合模型将apoB/apoA-1与传统的风险因素结合起来,在PCAD检测中实现了高AUC0.898.
结论:
- 与MHR,NLR和LDL-c/HDL-c相比,apoB/apoA-1比率是PCAD的一个优越的炎症生物标志物.
- 将apoB/apoA-1集成到风险评估模型中,可以显著提高PCAD的诊断准确性.
- 采用apoB/apoA-1的常规查可以改善PCAD的预防策略.
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