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新出现的挑战:高频率的杀菌剂耐药性编码基因和降低的Biguanide敏感性在抗生素耐药的Acinetobacter baumannii在伊朗

H Ghasemzadeh-Moghaddam^1,2, M Radmeher³, N Firouzeh¹

¹Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Archives of Razi Institute

|September 15, 2025

概括

来自ICU患者的Acinetobacter baumannii分离物显示出高比例的抗菌剂耐药性基因. 与这些基因有关的是氧二甲 (CHG) 等杀菌剂的最低抑制度 (MIC) 的升高,这给感染控制带来了挑战.

科学领域:

医学微生物学医学微生物学
传染性疾病传染性疾病
抗微生物耐药性抗微生物耐药性

背景情况:

宝曼尼菌 (Acinetobacter baumannii) 是导致医院感染的重要原因,特别是在重症监护室 (ICU).
多药耐药 (MDR) 和广泛耐药 (XDR) A. baumannii菌株的兴起是一个关键的临床挑战.
这些病原体的抗菌剂耐药性可能会危及感染控制措施.

研究的目的:

调查来自北霍拉桑省的A. baumannii分离物中抗菌耐药基因 (qacE,qacEΔ1,blaOXA-23) 的流行情况.
为了确定对四级和比古安化物化合物的耐药性水平,包括二氧化二甲酸 (CHG).
评估抗菌耐药性基因与最小抑制度 (MICs) 之间的相关性.

主要方法:

从北霍拉桑省的患者中收集了分离物.
选了特定的抗菌剂耐药性基因 (qacE,qacEΔ1,blaOXA-23) 的存在.
用微稀释方法来确定MIC对抗除菌化合物.

主要成果:

大多数A. baumannii感染 (84%) 发生在ICU患者中.
在53.2%和46.7%的分离物中,分别观察到MDR和XDR表型.
64%的分离物携带至少一个抗菌耐药性基因; qacE和qacEΔ1经常被检测到.
在具有耐药基因和没有耐药基因 (81.4微克/毫升与27.9微克/毫升,P=0.001) 的分离物之间发现了CHG平均MIC的统计学上显著差异.

结论:

显著比例的A. baumannii分离物,特别是在ICU中,携带抗菌剂耐药性基因.
对抗抗菌剂的MIC升高,如CHG,与这些耐药基因的存在有关.
这些发现强调,迫切需要持续监测A. baumannii分离的抗菌剂耐药性,以确保在医疗机构有效控制感染.

关键词:

抗菌剂耐药性抗菌剂耐药性巨化物化合物巨化物化合物具有多种耐药性的多种药物.这种细菌是Acinetobacter baumannii.这是什么? qacEE.qacEΔ1 的时间.

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