饮食因素,代谢因素,睡眠障碍,体力活动和多发性硬化症风险之间的关联:一个无变和多变的门德尔随机化研究
Hongwei Liu1, Minghui Wu1, Jie Yang1
1Department of Neurology Taiyuan City Central Hospital, the Ninth Clinical Medical College of Shanxi Medical University Taiyuan Shanxi Province China.
Food science & nutrition
|September 15, 2025
概括
这项研究使用了门德尔的随机化来研究生活方式因素和多发性硬化症 (MS) 之间的因果关系. 适度至剧烈的体力活动可能会降低MS风险,而较高的BMI,猪肉摄入量和2型糖尿病可能会增加MS风险.
科学领域:
- 神经学 神经学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 观察性研究表明,睡眠,饮食,新陈代谢,体力活动和多发性硬化症 (MS) 之间存在联系.
- 这些关联的因果关系需要进一步研究.
- 门德尔随机化 (MR) 提供了一种利用遗传变异探索潜在因果关系的方法.
研究的目的:
- 为了确定睡眠障碍,饮食因素,代谢因素和体力活动是否因果关系地影响患多发性硬化症 (MS) 的风险.
- 采用双样本门德尔随机化来评估这些潜在的因果关系.
主要方法:
- 使用两个样本的门德尔随机化 (MR) 分析.
- 研究了29个与睡眠,饮食,新陈代谢和身体活动相关的独特特征.
- 采用反变量加权 (IVW) 方法作为主要的分析方法.
主要成果:
- 统一的MR表明了时间型,猪肉摄入量,鱼/肝油补充剂,BMI,2型糖尿病 (T2DM),部周长,睡眠时间和中度至剧烈的体力活动 (MVPA) 与MS风险之间的关联.
- 多变量MR证实了猪肉摄入量,BMI,T2DM和MVPA与MS风险的强有力的因果关联,在对混因素进行调整后.
- 在多变量分析中,对时间型,鱼/肝油补充剂,部周长和睡眠时间的初始关联并不显著.
结论:
- 某些因素表明与MS风险存在潜在的因果关系.
- 增加中度至剧烈的体力活动可能与MS风险降低有关.
- 较高的BMI,增加的猪肉消费,以及2型糖尿病病史可能与MS风险增加有关.
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