关于饮食因素与尿路微积分风险之间的因果关系的新见解:多变量和两步门德尔随机化分析

Xinling Tang¹, Youjia Qiu², Bingyi Song²

¹Department of Urology Surgery The First Affiliated Hospital of Soochow University Suzhou Jiangsu Province China.

Food science & nutrition

|September 15, 2025

概括

这项研究使用了门德尔的随机化来研究饮食因素和尿道结石 (UC). 研究结果显示,咖啡,茶,水果和白葡萄酒的摄入可能会降低结石的风险,而可以调解一些影响.

科学领域:

遗传学是一个遗传学.
营养流行病学营养流行病学
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

观察性研究表明,饮食习惯与尿路结石 (UC) 有关.
饮食和UC之间的因果关系仍然不清楚.
遗传关联数据提供了一个强大的工具来探索因果关系.

研究的目的:

通过使用孟德尔随机化来评估各种饮食因素对尿路结石的因果关系.
通过多变量MR识别对UC的独立饮食影响.
通过常见生物标志物探索潜在的调解途径.

主要方法:

使用全基因组关联数据,采用双样本的门德尔随机化 (MR).
多变量MR (MVMR) 用于确定独立的饮食影响.
两步MR分析研究了30种常见生物标志物的调解.

主要成果:

基因预测的酒精,咖啡,茶,水果的摄入量,以及对白酒的偏好与脏和尿道结算相反相关.
对某些水果和加糖咖啡的偏好与下尿路结石有关.
MVMR证实了咖啡,精神活性饮料和水果对脏/尿道结石的独立保护作用,以及水果偏好对下尿路结石的独立保护作用.
部分调解了水果和干水果摄入量对UC的影响.

结论:

这项研究提供了强有力的遗传证据,证明特定的饮食因素在尿路结石发育中的保护作用.
研究结果强调咖啡,茶和水果的消费对UC有潜在的保护作用.
成为饮食对UC影响的潜在媒介,为预防策略提供了新的途径.

关键词:

门德尔的随机化分析分析.血液中的代谢产物.饮食因素饮食因素尿道结石尿道结石

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