益生菌在治疗口腔炎中的有效性:对随机对照试验的系统审查
Georgios Passadakis1, Chariklia Neophytou2, Sotiria Davidopoulou3
1Dentist, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Journal of International Society of Preventive & Community Dentistry
|September 15, 2025
概括
益生菌有效地减少挥发性硫化合物 (VSCs),改善呼吸气味得分,为口臭提供安全的治疗方法. 需要进一步的研究来确定长期的临床疗效和最佳的菌株选择.
科学领域:
- 口腔健康 口腔健康
- 微生物学 微生物学
- 临床试验 临床试验
背景情况:
- 由挥发性硫化合物 (VSCs) 引起的炎,影响全球人口的很大一部分.
- 传统的治疗方法提供了暂时的缓解,引发了对益生菌等生物疗法的兴趣.
- 益生菌调节口腔微生物群,为口臭管理提供了潜在的替代方案.
研究的目的:
- 系统地评估益生菌单一疗法的有效性,以减少与口臭相关的VSC水平和体感测试 (OLT) 评分.
- 在随机对照试验 (RCT) 中评估益生菌对口腔微生物群组成的影响.
主要方法:
- 根据PRISMA指南,在主要数据库中进行了全面的文献搜索.
- 包括对系统和牙周健康成年人的益生菌与安慰剂进行比较的RCT.
- 主要结局包括VSC水平和OLT得分的变化;使用Cochrane RoB 2工具评估偏差风险.
主要成果:
- 在六个可循环试验中的五个 (n=360) 在益生菌干预下显示出显著的VSC减少 (P <0.05).
- 三项研究报告了OLT得分的改善,其中特定的菌株如*Streptococcus salivarius* K12和*Weissella cibaria*显示出有希望的结果.
- 四项研究证实了微生物组的变化,治疗后持续的影响,没有严重的不良事件.
结论:
- 益生菌显著降低VSCs,增强OLT得分,调节口腔微生物群,表明口臭的安全辅助疗法.
- 研究的异质性和有限的长期随访需要更大的,标准化的临床转化试验.
- 未来的研究应该优先考虑纵向研究,特定益生菌菌株的疗效,以及针对微生物群的干预措施.
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