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高心血管疾病风险人群中的HDL-C/LDL-C比率和全因死亡率:一个前性观察性队列研究

Biting Lin^1,2,3, Yunzhi Ling^2,3, Gengyu Zhou^2,3

¹Fujian University of Traditional Chinese Medicine Fuzhou Fujian China.

Chronic diseases and translational medicine

|September 15, 2025

概括

高密度脂蛋白胆固醇 (HDL-C) 与低密度脂蛋白胆固醇 (LDL-C) 的比率预测心血管疾病 (CVD) 风险,但这种联系在2型糖尿病 (T2DM) 患者中没有发现. 保持HDL-C/LDL-C比率在0.3-0.5之间对于没有T2DM的高风险心血管疾病群体是有益的.

科学领域:

心血管医学心血管医学
代谢障碍代谢障碍代谢障碍
流行病学流行病学

背景情况:

建立了高密度脂蛋白胆固醇 (HDL-C) 与低密度脂蛋白胆固醇 (LDL-C) 的预后值,用于心血管疾病 (CVD) 终点.
然而,它在高风险人群中的预测有效性以及与2型糖尿病 (T2DM) 相关的不良事件仍然不清楚.

研究的目的:

调查中国高风险心血管疾病人群中HDL-C/LDL-C比率与全因死亡率之间的关联.
为了确定这种关联是否在T2DM和没有T2DM的个体之间有所不同.

主要方法:

分析了32609名年龄在35-75岁之间,患心血管疾病高风险的人群.
考克斯的比例危险模型和受限立方线 (RCS) 分析被用来评估HDL-C/LDL-C比率与死亡率之间的相关性.
参与者被分为低 (<0.3),中 (0.3-0.5) 和高 (>0.5) HDL-C/LDL-C比率组.

主要成果:

与中间组相比,在低 (HR=1.48) 和高 (HR=1.30) HDL-C/LDL-C比率组中观察到所有原因死亡的风险增加.
这种关联在没有T2DM的高风险心血管疾病患者中是显著的 (低比率:HR=1.65;高比率:HR=1.35).
在患有T2DM的高风险心血管疾病患者中,HDL-C/LDL-C比率和死亡率之间没有显著的关联.

结论:

HDL-C/LDL-C比率可以预测高风险心血管疾病患者的预后.
对于这个人群来说,0.3到0.5之间的比率似乎是最有益的.
这一比率在没有T2DM的个体中具有临床意义,但对T2DM队列需要进一步研究.

关键词:

高密度脂蛋白胆固醇 (HDL-C) 是一种低密度脂蛋白胆固醇 (LDL-C) 是一种低密度脂蛋白胆固醇.患心血管疾病高风险的人群.预后预后预后二型糖尿病 (T2DM) 是一种糖尿病.

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