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免疫相关的内微生物群和宿主基因表达对癌症预后的影响

Qingzhen Fu¹, Ning Zhao¹, Xia Li¹

¹Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.

|September 15, 2025

概括

内微生物群通过改变宿主基因表达和瘤微环境免疫力,影响癌症预后. 一个新的微生物评分预测患者的生存率和免疫细胞透率,为个性化癌症治疗提供了潜在的潜力.

科学领域:

在瘤学瘤学.
微生物组研究微生物组研究
生物信息学是一种生物信息学.

背景情况:

瘤微环境 (TME) 包括内微生物群,但其在宿主基因表达,TME免疫力和癌症预后方面的作用尚未完全理解.
研究内微生物群与宿主因子之间的相互作用对于推进癌症研究和治疗策略至关重要.

研究的目的:

阐明内微生物群与宿主基因表达之间的关系.
开发基于微生物组成的癌症预后和TME免疫力的预测得分.
探索内微生物群影响癌症结果的机制.

主要方法:

利用机器学习框架在癌症基因组图谱 (TCGA) 和基因表达总 (GEO) 数据集中识别微生物群-宿主基因关联.
开发了一种泛癌免疫和预后相关微生物评分 (IPRMS) 和癌症特异性IPRMS.
进行了生存介导分析 (SMAs) 来调查预后机制.

主要成果:

鉴定了与微生物群相关的基因子集,富含免疫和细胞信号通路.
全癌症IPRMS表明,高IPRMS患者的预后较差,巨细胞和癌症相关纤维细胞增加,瘤透性淋巴细胞减少.
单细胞分析显示,高IPRMS组中的癌症相关纤维细胞和低IPRMS组中的瘤透淋巴细胞的丰富.

结论:

内微生物群显著影响宿主基因表达,TME免疫力和癌症预后.
开发的IPRMS可以作为预测患者存活率和指导个性化癌症治疗的潜在生物标志物.
免疫细胞,免疫通路和宿主基因的微生物群驱动的修改是影响癌症进展的关键机制.

关键词:

在TCGA中,TCGA就是TCGA.宿主基因表达方式免疫力是一种免疫力.肠道内口微生物群预后预后预后一个单细胞的单细胞.生存调解协会生存调解协会

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