儿童特纳综合征患者的神经发育和心理健康诊断:一项PEDSnet研究
Christa Hutaff-Lee1,2,3, Morgan Jolliffe1,2, Karli S Swenson1,2
1University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
American journal of medical genetics. Part A
|September 15, 2025
概括
患有特纳综合征 (TS) 的年轻人患神经发育障碍 (NDD) 的比率更高,包括语言,运动和注意力问题. 然而,与对照人群相比,TS患者的焦虑和情绪障碍等心理健康 (MH) 状况并不比TS患者更常见.
科学领域:
- 儿科健康 儿科健康
- 遗传学 是一个遗传学.
- 神经发育障碍 神经发育障碍
背景情况:
- 特纳综合征 (TS) 与神经发育障碍 (NDD) 和心理健康 (MH) 状况的风险增加有关.
- 有限的基于人口的儿科数据存在于TS的NDD和MH.
研究的目的:
- 与匹配的对照组相比,检查TS青少年中NDD和MH诊断的流行率.
- 在一个大型儿科队列中确定与TS相关的特定NDD和MH条件.
主要方法:
- 对六个美国儿科卫生系统的数据进行了回顾性分析.
- 在2145名TS青少年中,NDD和MH诊断的比较与8580名匹配的女性对照.
- 使用概括估计方程计算几率比率 (OR) 和95%置信区间 (CI) 的统计分析.
主要成果:
- 患有TS的年轻人患有NDD诊断的几率显着更高 (OR 2.37),特别是言语语言,运动,学习和注意力障碍.
- 观察到自闭症谱系障碍 (ASD) 和智力发育障碍 (IDD) 的几率增加,但仍然不常见.
- 患有TS的年轻人与对照人群 (OR 0.92) 之间精神健康诊断 (焦虑,情绪障碍) 的流行率没有显著差异.
结论:
- 这些发现强调了对TS患者进行主动神经发育查的必要性.
- 类似的MH诊断的流行率需要进一步调查潜在的不足诊断或TS的不同呈现.
- 需要进行额外的研究,以了解TS青少年的MH症状表现和时机.
相关概念视频
Autism Spectrum Disorder
987
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
987
Attention-Deficit/Hyperactivity Disorder
787
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
787
Conduct Disorder
490
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
490
Oppositional Defiant Disorder
642
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Diagnostic Criteria and...
642
Meiosis vs. Mitosis
69.4K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
69.4K


