基于对抗生素敏感性的Helicobacter pylori第三线成功根除的特征
Keita Suzuki1, Ai Fujimoto1, Hideki Mori2
1Department of Gastroenterology and Hepatology, Division of Internal Medicine, Toho University Omori Medical Center, Tokyo, Japan.
Asian Pacific journal of cancer prevention : APJCP
|September 15, 2025
概括
使用vonoprazan (VPZ),阿莫西西林 (AMX) 和西塔弗洛克萨辛 (STFX) 进行的第三线Helicobacter pylori根除取得了79.2%的成功率. 女性患者和AMX敏感的H. pylori患者更有可能成功根除.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 对持续性感染来说,H. pylori的第三线根除至关重要.
- 在日本使用的疗法包括vonoprazan (VPZ),阿莫西西林 (AMX) 和sitafloxacin (STFX).
- 关于这些特定的第三线疗法的现实结果的数据有限.
研究的目的:
- 评估第三线H. pylori根除方案的有效性.
- 为了确定与成功根除相关的患者特征.
- 为了比较不同第三线治疗策略之间的结果.
主要方法:
- 进行了一项单一中心的回顾性观察性研究.
- 分析了在2013-2020年期间接受第三线H. pylori根除的患者.
- 审查了抗生素敏感性测试和临床数据.
主要成果:
- 第三线根除总体成功率为79.2% (42/53).
- 与基于质子抑制剂 (PPI) 的疗法 (64.3%) 相比,诺普拉赞 (VPZ),阿莫西西林 (AMX) 和西塔弗洛克萨辛 (STFX) 疗法显示出更高的成功率 (89.7%).
- 女性性别和阿莫西西林敏感性与成功根除有显著的关联.
结论:
- VPZ,AMX和STFX联合治疗是一种有效的第三线H. pylori根除策略.
- 女性性别和阿莫西西林敏感性等患者因素会影响治疗的成功.
- 进一步的研究可以优化第三线H. pylori治疗方案.
相关概念视频
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
1.2K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.2K
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
541
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
541
01:23Gastritis III: Clinical Manifestations and Management
1.2K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.2K
01:30Development of Antibiotic Resistance
1.3K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.3K
01:26Peptic Ulcer Disease IV: Management
439
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
439
01:28Antimicrobial Effectiveness
908
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
908