调节的加勒素1和3的表达与肺结核和多结核病中调节不良的T细胞反应有关
Matilde Imhoff1,2, Magdalena N Diab1, Georgina Gallucci2
1Instituto de Inmunología Clínica y Experimental de Rosario (IDICER), Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Nacional de Rosario, Suipacha 590, Rosario, Santa Fe, Argentina.
Medical microbiology and immunology
|September 15, 2025
概括
结核病 (TB) 患者表现出质素 (Gal-1和Gal-3) 和免疫媒介的水平变化. 单核细胞中加勒素和相关酶的这些变化可能会影响肺结核中的免疫细胞功能.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 分子生物学分子生物学
背景情况:
- 在各种病理中,盖लेक्ट因调节免疫细胞功能.
- 它们在结核病 (TB) 等慢性感染中的作用不太清楚.
- 研究结核病中的甲素可以揭示对疾病机制的新见解.
研究的目的:
- 评估肺结核 (PTB) 和肺结核 (PLTB) 患者的加勒-1 (Gal-1) 和加勒-3 (Gal-3) 水平和表达.
- 为了分析免疫媒介和与糖化相关的酶表达与 galectins 相关.
- 了解加勒素对结核病免疫细胞功能的影响.
主要方法:
- 从PTB,PLTB患者和健康对照组 (HCo) 收集了血和多液样本.
- 测量了单核细胞 (MCs) 中的盖莱克度,免疫媒介和与盖莱克相关的酶表达 (MGAT5,GCNT1,ST6GAL1).
- 用Mycobacterium tuberculosis (Mtb) 刺激单核细胞以评估Gal-1的产生.
主要成果:
- 结核病患者表现出高循环的亲和抗炎媒介和减少细胞增殖.
- PTB患者在MC中显示了血Gal-1的增加和更高的Gal-1mRNA.
- 这两组结核病患者的血Gal-3含量高,MC表达量增加;胸腔液的含量较低.
- PTB PBMCs显示了改变的GCNT1和ST6GAL1表达,这表明加勒素配体的可用性增加.
- 结核病患者的mtb刺激的MCs产生了更多的Gal-1,而PTB显示出更高的基底产量.
结论:
- 在结核病患者中,循环中的甲状腺素和免疫媒介物发生变化.
- 单核细胞中加列和糖化酶的差异表达可能会影响免疫细胞的功能,特别是在PTB中.
- 甲状腺素代表了结核病的潜在生物标志物和治疗点.
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