帕金森病中的视网膜微血管变化:视觉分析和元分析
Shiyuan Qin1, Lei Li1, Shuang Gao1
1Department of Neurology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650031, China.
概括
光学连贯断层扫描血管造影 (OCTA) 显示帕金森病 (PD) 患者的表面毛细血管密度降低. 这种非侵入性成像显示了早期PD诊断和监测疾病进展的潜力.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 医疗成像医学成像
背景情况:
- 光学连贯断层扫描血管学 (OCTA) 是一种新兴的技术,用于评估神经退行性疾病中的微血管变化.
- 在帕金森病 (PD) 中越来越多地报告了视网膜微血管异常.
研究的目的:
- 通过视觉分析和元分析,确定OCTA在PD中的应用研究趋势.
- 评估视网膜血流变化作为PD的潜在早期诊断标志物.
主要方法:
- 在PubMed,Scopus和Web of Science的系统文献搜索.
- 使用VOSviewer,CiteSpace和RevMan 5.4.4进行的28项研究的视觉分析和19项研究的元分析.
- 关键词,研究趋势和视网膜微血管学定量数据的分析.
主要成果:
- 视觉分析表明,PD中OCTA的研究重点越来越大.
- 分析显示,PD患者的表面毛细血管 (SCP) 密度显著降低.
- 对于深层毛细管 (DCP) 和状无血管区 (FAZ) 的可变发现;微血管密度和PD严重程度之间的相关性.
结论:
- OCTA是用于早期PD诊断和监测的非侵入性,客观的工具.
- 在帕金森病的临床前阶段,OCTA具有潜在的临床应用.
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