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肌肉内脂肪组织:从祖先到病理

Hailey G Jones¹, Daniel Kopinke¹, Gretchen A Meyer^2,3

¹Department of Pharmacology and Therapeutics, Myology Institute, University of Florida, Gainesville, Florida, United States.

American journal of physiology. Cell physiology

|September 15, 2025

概括

肌内脂肪组织 (IMAT) 积累积极促进肌肉功能障碍和代谢问题. 了解控制脂肪细胞原始体 (FAPs) 的分子信号是开发新疗法的关键.

科学领域:

肌肉生理学和病理学
细胞和分子生物学是细胞和分子生物学.
翻译医学是一种翻译医学.

背景情况:

肌内脂肪组织 (IMAT) 积累在骨肌疾病中很常见,与功能不良和代谢问题有关.
一个关键的辩论是,IMAT是肌肉病理学的被动标记者还是积极驱动者.
现有的动物模型往往无法复制人类IMAT病理,这给翻译带来了挑战.

研究的目的:

审查IMAT在肌肉病理学中的作用的证据.
探索IMAT诱导的肌肉功能障碍的机制.
检查IMAT的细胞起源和调节.

主要方法:

文献综述综合人类和动物研究结果.
分析IMAT损害肌肉功能的机制 (身体障碍,膜信号).
研究纤维/基原体 (FAPs) 作为IMAT和监管信号网络的细胞源.

主要成果:

IMAT既是物理障碍,也是肌肉中破坏性膜信号的来源.
纤维/基原体 (FAPs) 在病理条件下可以分化为脂肪细胞.
控制FAP命运的信号通路的调节失调有助于IMAT积累.

结论:

新出现的证据强烈表明IMAT是肌肉衰减的积极贡献者.
未来的研究应该专注于确定FAP命运的分子"制动器"和"触发器".
开发更好的临床前模型和标准化的IMAT量化方法对于临床进展至关重要.

关键词:

在 IMAT 和 IMAT 中,您可以使用 IMAT.脂肪的透脂肪的透纤维/基原始原始体.肌肉间脂肪组织的脂肪组织.肌肉退化肌肉退化

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