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从Panax人参中选DPP4抑制剂,使用亲和力超选选与UPLC-ESI-Orbitrap-MS方法相结合

Hong-Ping Wang1, Chen Zhao1, Zi-Jian Wang1

  • 1Department of Drug Screening and Development, Scientific Research Institute of Beijing Tongrentang Co., Ltd, Beijing, China.

Natural product research
|September 15, 2025
PubMed
概括

这项研究确定了Panax人参中的oleanane类型的人参化物作为二二二酶-4 (DPP4) 的抑制剂. 这表明了这些化合物如何在糖尿病治疗中降低血糖的新机制.

关键词:
DPP4 抑制剂的使用这就是LC-MS.帕纳克斯人参是一种人参.亲缘关系超过查选人参酸性enosides 是一种

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Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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