一项实用性临床试验的设计和协议,以改善初级保健中认知障碍的检测
Bethany Crouse1, Rebecca C Rossom1, A Lauren Crain1
1HealthPartners Institute, 8170 33(rd) Ave S, Minneapolis, MN, USA.
Contemporary clinical trials
|September 15, 2025
概括
临床决策支持系统 (CDSS) 可以改善初级保健机构的认知障碍 (CI) 的早期检测和管理. 这项研究评估了CDSS干预措施,以增加CI诊断率并提高患者护理.
科学领域:
- 老年学是一门学科.
- 临床信息学 临床信息学
- 神经学 神经学
背景情况:
- 全球认知障碍 (CI) 的流行率不断上升,包括阿尔茨海默病 (AD) 和相关痴呆症 (ADRD).
- 未诊断的CI增加了患者和家庭的负担.
- 临床决策支持系统 (CDSS) 有潜力改善CI的初级保健.
研究的目的:
- 评估CDSS在提高初级保健中CI检测方面的有效性.
- 改善初级保健临床医生 (PCC) 对CI的识别,评估,诊断和管理.
主要方法:
- 实用性,集群随机化,III期临床试验,涉及38个初级保健诊所.
- 干预组接受了CI-CDSS和培训;对照组接受了通常的护理 (UC).
- CI-CDSS使用EHR数据和预测模型来识别高风险患者,提供诊断和管理工具.
主要成果:
- 主要结局:18个月后CI诊断的EHR文档.
- 二次结果:医疗保健成本和PCC对CI诊断和管理的信心.
结论:
- 该研究评估了CDSS以增加初级保健中CI检测.
- 成功实施可能会导致CI诊断和管理的改进,个性化的建议,提高患者护理.
相关概念视频
01:11Clinical Trials: Overview
4.6K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.6K
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
560
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
560