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Updated: Jan 17, 2026

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斯坦诺-1,2,3-三醇衍生物:合成,瘤细胞中的DNA损伤和抗前列腺癌活性研究研究

Xixi Hou1, Shuxiang Xu2, Longfei Mao3

  • 1Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P.R. China; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan 471003, P.R. China.

Bioorganic & medicinal chemistry letters
|September 15, 2025
PubMed
概括

具有1,2,3-triazole结构的新型斯坦诺龙衍生物显示出强大的抗前列腺癌活性. 化合物14k在体内和体外表现出显著的疗效,没有观察到对正常细胞的毒性.

关键词:
1,2,3-三醇是一种这是一种抗瘤药物.造成的DNA损伤是DNA损伤.前列腺癌细胞前列腺癌细胞斯坦诺龙 (Stanolone) 是一种可靠的药物.

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