2025年个体辐射敏感性测试:个性化放射治疗的当前进展和未来方向
Kamel Debbi1, Nhu Hanh To1, Allan Thiolat2
1Department of Radiation Oncology and Henri Mondor Breast Center, Henri Mondor University Hospital, APHP, UPEC, Créteil, France; Institut Mondor de Recherche Biomédicale (IMRB), INSERM U955, i-Biot, UPEC, Créteil, France.
Critical reviews in oncology/hematology
|September 15, 2025
概括
预测个人辐射敏感性 (RS) 是个性化放射治疗的关键. 最近的进展显示出有前途,辐射诱导淋巴细胞亡 (RILA) 试验是预测治疗毒性的最有临床验证的方法.
科学领域:
- 在瘤学瘤学.
- 辐射生物学 辐射生物学
- 生物标志物发现发现
背景情况:
- 个性化辐射瘤学依赖于预测个体的放射敏感性 (RS).
- 临床实施受到生物标志物的变化和缺乏共识的阻碍.
- 本综述考察了RS预测的近期进展及其临床相关性.
研究的目的:
- 综合辐射敏感性预测方面的进展.
- 评估各种生物标志物的转化潜力和临床适用性.
- 批判地评估当前RS预测方法的验证状态和局限性.
主要方法:
- 进行了对1980-2025年文学作品的叙事评论.
- 搜索包括PubMed/MEDLINE和放射生物学期刊.
- 分析的主要主题是遗传标记物,功能分析,衰老生物标记物和奥米克技术.
主要成果:
- 辐射诱导的淋巴细胞亡 (RILA) 试验与晚期毒性 (乳腺纤维化AUC=0.72) 有着强烈的相关性.
- 纤维细胞测定 (SF2,ATM转位) 提供组织特定的预测.
- 衰老标记和奥米克签名提供了机械洞察力,但需要标准化.
结论:
- 放射性敏感性预测正在向临床实用性迈进,RILA是领先的验证试验.
- 未来的工作需要多中心验证,具有成本效益的omics和生物标志物引导的适应性试验.
- 在放射性瘤学中优化治疗比率是最终的目标.
相关概念视频
Combination Therapies and Personalized Medicine
5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K


