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Updated: Jan 17, 2026

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过度活跃的PDGFRβ信号会通过TGFβ和STAT5-IGF1诱导白内障发生

Jesse J Reardon1, Yixuan Ma2, Nathaniel S Grabinski1

  • 1The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Radiation Oncology, The Ohio State University, Columbus, OH, USA.

Developmental biology
|September 15, 2025
PubMed
概括

血小板衍生生长因子受体β (PDGFRβ) 的激活通过促进透镜纤维化导致白内障. 这涉及通过TGFβ,Wnt/β-catenin,SOCS2和STAT5-IGF1信号通路调解的细胞外基质变化.

关键词:
白内障是什么?白内障是什么?白内障是什么?IGF1 IGF1 的意思是什么镜片的表皮是镜片的表皮.这是PDGFRββ.在STAT5中,我们使用了STAT5.在TGFβ中,TGFβ是TGFβ.

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