宫食道状细胞癌的内镜切除后的长期结果
Yoshiaki Ando1, Minoru Kato1, Yasuhiro Tani1
1Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Gastrointestinal endoscopy
|September 15, 2025
概括
宫食道状细胞癌 (ESCC) 的内镜切除 (ER) 显示出有希望的长期结果. 更深层次的侵袭或淋巴血管侵袭 (LVI) 可能需要进一步治疗以防止复发.
科学领域:
- 胃肠病学和内镜检查
- 在瘤学瘤学.
- 手术瘤学手术瘤学
背景情况:
- 对于宫食道状细胞癌 (ESCC) 的内镜切除 (ER) 的长期结果存在有限的数据.
- 根据侵袭深度和淋巴血管侵袭 (LVI) 的分层对评估ER疗效至关重要.
研究的目的:
- 调查ER对表面宫ESCC的长期结果.
- 根据入侵深度和LVI.来分层结果.
主要方法:
- 对131名用ER治疗的T1宫ESCC患者的回顾性分析.
- 根据病理诊断分组患者:pT1a-EP/LPM没有LVI (A组),pT1a-MM没有LVI (B组),pT1a-MM有LVI或pT1b-SM1/SM2 (C组).
- 组间的整体存活率 (OS),疾病特异性存活率 (DSS) 和无复发存活率 (RFS) 的比较.
主要成果:
- 随访时间中位数为64个月.
- 组A和B (没有LVI) 没有转移性复发,也不需要额外的治疗.
- 组C (具有LVI或更深的入侵) 显示出更高的复发率,7%经历化学辐射疗法 (CRT) 后的复发和25%没有CRT.
- 5年DSS在C组 (92%) 与A组和B组 (100%) (P=.046) 相比显著较低.
结论:
- 内镜切除为选择早期宫ESCC提供了有利的长期结果.
- 患有LVI或更深入入侵的患者 (pT1b) 需要仔细考虑辅助治疗.
- 用ER治疗的宫ESCC的结果与胸部ESCC报告的结果相似.
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