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Updated: Jan 17, 2026

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
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抗体与药物合物的依赖有效载荷的光稳定性

Carl Oliver Thiess1, Karsten Mäder2, Hanns-Christian Mahler3

  • 1Martin-Luther University Halle-Wittenberg, Institute of Pharmacy, Wolfgang-Langenbeck-Strasse 4, 06120 Halle (Saale), Germany; Global CMC Development, Merck KGaA, Frankfurter Straße 250, 64293 Darmstadt, Germany.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
|September 15, 2025
PubMed
概括

含有Exatecan有效载荷的抗体药物联合体 (ADC) 由于有效载荷作为光敏感剂,显示出显著的光降解. 这凸显了在ADC开发中研究有效载荷稳定的必要性.

关键词:
抗体与药物的结合物.在Camptothecin的营地里.一个DM1的DM1埃克萨特是一种.光敏度 对于光的敏感度在MMAE中,MMAE是最重要的.单克隆抗体是一种单克隆抗体.实用载荷是可以使用的.照相降解是一种光降解.光敏化剂是一种光敏化剂.

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