1型糖尿病控制不良的青少年的骨健康:随机对照试验的结果
Mari-Anne Pulkkinen1,2, Tero Varimo1,2, Sanna Toiviainen-Salo1
1Children's Hospital, Pediatric Research Center, Helsinki University Hospital, Helsinki, Uusimaa, Finland.
在青少年中控制不良的1型糖尿病与较低的骨密度有关. 增加的胰岛素样生长因子I (IGF-I) 与骨积累有关,但血糖控制和AGE并不是显著的因素.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 骨的健康 骨的健康
背景情况:
- 控制不良的1型糖尿病 (T1D) 与骨健康受损有关.
- 连接T1D与骨健康的机制尚未完全理解.
- 研究血糖控制,葡萄糖变性,IGF-I和AGE在T1D骨积累中的作用至关重要.
研究的目的:
- 调查T1D青少年的血糖控制,葡萄糖变化和骨健康之间的关联.
- 评估胰岛素样生长因子I (IGF-I) 和高级糖化最终产品 (AGEs) 在T1D骨矿物积累中的作用.
主要方法:
- 长度研究青少年的T1D控制不良 (HbA1c>9%).
- 双能X射线吸收计 (DXA) 用于基线和12个月的骨矿物密度 (BMD) 评估.
- 血糖控制 (HbA1c,CGM),血清IGF-I和AGE (MG-HI) 被测量并与骨参数相关联.
主要成果:
- 与参考值相比,患有T1D的青少年的BMDz分数较低.
- 增加IGF-I与骨矿物质密度积累有关.
- HbA1c,时间范围或MG-HI的变化与骨健康指标没有显著的关联.
结论:
- 尽管T1D青少年的BMD较低,但血糖控制和MG-HI与骨健康没有相关性.
- 增加的IGF-I与T1D中改善的骨积累有关.
- 需要进一步研究替代AGE和先进的骨图像,以了解T1D骨脆弱性.
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