在膀瘤微环境中,MAIT细胞促进癌症的进展和调节性T细胞的积累
Inbar A Habaz1, Xuejin Ou1,2, Nicole I Wang1
1Department of Microbiology and Immunology, Western University, London, Ontario, Canada.
Journal for immunotherapy of cancer
|September 15, 2025
概括
粘膜相关的不变T细胞 (MAIT) 在膀癌 (BCa) 中丰富,促进瘤生长. 这些发现表明MAIT细胞在BCa中起着前瘤的作用,可能是通过增加调节性T细胞.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 粘膜关联不变T细胞 (MAIT) 是与先天类似的淋巴细胞,参与屏障组织的免疫反应.
- MAIT细胞可以影响瘤微环境,但它们在膀癌 (BCa) 中的作用尚不清楚.
研究的目的:
- 研究MAIT细胞在膀癌中的存在和作用.
- 确定MAIT细胞是否有助于BCa中的瘤进展或抑制.
主要方法:
- 使用TCR Vα7.2染色检测人类BCa活检中的MAIT细胞.
- 对RNA测序数据的生物信息分析,以将MAIT细胞丰度与BCa患者存活率相关联.
- 使用BCa的小鼠模型来评估MAIT细胞充足与MAIT细胞缺乏条件中的瘤负担.
- 功能性MAIT细胞耗尽使用乙-6-formylpterin (Ac-6-FP) 和通过MRI和组织学评估瘤进展.
主要成果:
- 在BCa活检中检测到MAIT细胞,较高的MAIT细胞透与较差的患者存活率相关.
- 与MAIT细胞缺乏或枯竭的小鼠相比,具有MAIT细胞充足的小鼠表现出更大的BCa瘤负担.
- 瘤携带小鼠的膀MAIT细胞显示出MAIT17表型,增加IL-17A和TNF-α的产生.
- 在富含MAIT细胞的BCa瘤中观察到FoxP3+调节T (Treg) 细胞的高频率,这表明免疫抑制的微环境.
结论:
- 在BCa瘤微环境中存在MAIT细胞.
- MAIT细胞促进BCa中的瘤进展,可能是通过增强Treg细胞积累和培养免疫抑制环境.
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