蔓越通过调节AMPK/SREBP1,ROCK1和TGF-β1来改善与代谢综合征相关的老鼠器官功能障碍
Sahar M Elashmony1, Yosra Alhindi2, Dina H Merzeban3
1Medical Pharmacology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Scientific reports
|September 15, 2025
概括
蔓越提取物通过改善关键健康标志物和保护器官,在治疗代谢综合征 (MetS) 中表现有前途. 它的效果与甲福明相似,这表明它是一种安全,天然的治疗方法.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 病理学 病理学 病理学
背景情况:
- 代谢综合征 (MetS) 是一个重大的全球健康挑战,增加医疗保健成本和降低生活质量.
- 迫切需要 MetS 的有效预防和管理策略.
研究的目的:
- 为了研究蔓越提取物 (Vaccinium macrocarpon) 和甲胺在MetS.的老鼠模型中的治疗潜力.
- 评估蔓越和甲胺对代谢参数,器官病理和与MetS相关的分子途径的影响.
主要方法:
- 通过使用高脂肪和高果糖饮食,然后注射 estreptozotocin,建立了MetS的老鼠模型.
- 鼠被用不同剂量的蔓越提取物或甲胺治疗了四周.
- 评估包括代谢分析,器官组织病理学,以及基因表达 (Rock1,Srebf1) 和蛋白质标记物 (iNOS,TGF-β1) 的分析.
主要成果:
- 引发MetS导致体重增加,BMI,葡萄糖不耐受,脂质不良,肌氨酸升高和高血压.
- 观察到肝脏和脏结构异常,以及原和iNOS/TGF-β1表达的增加.
- 蔓越提取物剂量依赖地改善了代谢参数,上调AMPK,下调Rock1和Srebf1,改善了器官损伤,并减少了iNOS/TGF-β1表达,结果与甲胺相当.
结论:
- 蔓越提取物显示出对管理MetS的显著治疗潜力.
- 它提供了广泛的益处,包括器官保护和关键分子通路的调制.
- 蔓越提取物代表了一种有希望的,安全的,自然的替代物,用于MetS管理.
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