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Updated: Jan 17, 2026

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis
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在aptamer选择中测试三维cyclooctatetraene的核基修饰

Greta Charlotte Dahm1, Usman Akhtar1,2, Alix Bouvier-Müller1

  • 1Institut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, Paris Cedex 15, France.

Communications chemistry
|September 15, 2025
PubMed
概括

研究人员使用cyclooctatetraene carboxylate (COTc) 修饰开发了新型的体. 这些体表现出对PvLDH生物标志物的增强结合亲和力,在药物发现中为传统芳香化合物提供了一个有希望的替代品.

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Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping05:32

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Transfer RNA Synthesis02:36

Transfer RNA Synthesis

One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
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